"So God created man in his own image, in the image of God created he him; male and female created he them." (Genesis 1:27 KJV) The biology of our creation is true to God's design, even while the mind can be confused. Man and woman were created in His image as parts, only in becoming one flesh through marriage can that image be made whole. The Lord makes a case for those dysphoric in the world and scripture offers a path for them to thrive. Like all of us born of this mortal world, it is a long road with many dark valleys, and their confusion is their burden to bear. But the Lord's word and the community and ministry of fellow Christians can lessen that burden. Affirming one's identity as that which they were made is the path to salvation in Jesus Christ.
[P1] We should not alter God's design.