If scientists, physicians, and bioethicists communicated with people who have genetic conditions which could be treated with CRISPR, they could make informed decisions about what kinds of genetic conditions we should treat and which we should not. For instance, it is unlikely that anyone with multiple sclerosis or sickle cell anemia would advocate for allowing people to have those diseases. One of the biggest distinctions between conditions like Down syndrome and diseases like multiple sclerosis and sickle cell anemia is that diseases like the latter intrinsically cause suffering. Having Down syndrome does not inherently cause a person to suffer. Any suffering that is related to having Down syndrome has much more to do with society being unaccommodating to people with Down syndrome. Discrimination, alienation, and and not having the same rights as other people may be challenges for people with Down syndrome, but that does not mean that having Down syndrome is the same as having a genetic condition that inherently causes pain and suffering such as sickle cell anemia. Making the distinction between genetic conditions which inherently cause suffering and genetic conditions which may only cause suffering as a result of an unaccommodating society could allow us to use CRISPR ethically without worrying about unjustifiably eradicating certain genetic conditions.